Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG

Author(s): Michel, C. M., Wackermann, J., Koenig, T., Tanaka, H., Peuvot, J., Lehmann, D.

Journal/Book: Int J Psychophysiol. 1999; 34: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science Bv. 81-87.

Abstract: Global complexity of 47-channel resting electroencephalogram (EEG) of healthy young volunteers was studied after intake of a single dose of a nootropic drug (piracetam, Nootropil(R) UCB Pharma) in 12 healthy volunteers. Four treatment levels were used: 2.4, 4.8, 9.6 g piracetam and placebo. Brain electric activity was assessed through Global Dimensional Complexity and Global Omega-Complexity as quantitative measures of the complexity of the trajectory of multichannel EEG in state space. After oral ingestion (1-1.5 h), both measures showed significant decreases from placebo to 2.4 g piracetam. In addition, Global Dimensional Complexity showed a significant return to placebo values at 9.6 g piracetam. The results indicate that a single dose of piracetam dose-dependently affects the spontaneous EEG in normal volunteers, showing effects at the lowest treatment level. The decreased EEG complexity is interpreted as increased cooperativity of brain functional processes.

Note: Article Lehmann D, Univ Zurich, Hosp Psychiat, KEY Inst Brain Mind Res, Lenggstr 31, CH-8029 Zurich, SWITZERLAND

Keyword(s): human multichannel EEG; EEG state space; global omega complexity; global dimensional complexity; single dose piracetam; piracetam effects; brain dynamics; DIMENSIONAL COMPLEXITY; NOOTROPIC DRUG; STATE; SCHIZOPHRENIA; MAPS

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