The herbal medicine Sho-saiko-to inhibits growth and metastasis of malignant melanoma primarily developed in rat-transgenic mice

Author(s): Kato, M., Liu, W. , Yi, H. , Asai, N. , Hayakawa, A. , Kozaki, K. , Takahashi, M. , Nakashima, I.

Journal/Book: J Invest Dermatol. 1998; 111(4): 640-644.

Abstract: Sho-saiko-to is the most popular herbal medicine in Japan. We investigated the anti-tumor and anti-metastatic effects of Sho-saiko-to and its chemically defined ingredients on the primary skin melanoma that developed in a metallothionein-I ( MT)/ret transgenic mouse line and on a melanoma cell line (Mel-ret), which was derived from a primary tumor developed in a MT/ret transgenic mouse. In vitro, Sho-saiko-to suppressed the growth of Mel-ret cells more strongly than any single ingredient of Shosaiko-to, although baicalin as one of several ingredients tested also suppressed it significantly. In In vivo, Sho-saiko-to (i) significantly (p < 0.02) prolonged the onset of tumor developmen s.

Keyword(s): hom. br. exp. cam. phyto. anim. cancer. melanom. sho-saiko-to

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