Effects of a standardized mistletoe preparation on metastatic B 16 melanoma colonization in marine lungs

Author(s): Weber, K., Mengs, U. , Schwarz, T. , Hajto, T. , Hostanska, K. , Allen, T. R. , Weyhenmeyer, R. , Lentzen, H.

Journal/Book: Arzneim Forsch. 1998; 48(5): 497-502.

Abstract: The immune response-modifying drug Lektinol(R) is a mistletoe preparation which is standardized with respect to bioactive viscum album agglutinin, the most active component of mistletoe. The present study was designed to evaluate the antimetastatic effects of this preparation following intravenous injection of B16 melanoma cells into mice. The standardized mistletoe extract was administered intravenously in doses of 100, 1000 or 5000 mu l/kg (equivalent to ) thymocytes were significantly increased in animals treated with the standardized mistletoe extract. There were no signs of treatment-related toxicity. The results of this study indicate that the standardized mistletoe extract shows antimetastatic activity against B16 melanoma lung colonization.

Keyword(s): mistellektine.

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