The Treatment of Aseptic Bone Necrosis (AN) in Aged Rheumatoid Arthrits (RA) Patients

Journal/Book: Z Rheumatol 1998; 57 Suppl. 1: 72 (P 108). 1998;

Abstract: lnstitute of Rheumatology RAMS Moskow Long-term follow up of 141 RA patients (pts) - m/f-30/111 mean age 60.1 years (yrs) with the onset of disease after 50 yrs (mean duration of follow up 7.5 yrs) revealed AN in 32 pts (m/f-3/29 mean age at the onset of disease 57.6 yrs mean duration of follow up 10.2 yrs). All 32 pts had acute onset of disease generalized joint involvement. rheumatoid nodules (RN) and such systemic lesions. as early appearence of rheumatoid factor (RF) destrucive changes-in joints. Systemic manifestations had 21 (62 %) of pts RN - 10 vasculitis - 12 (in 3 with trophic ulcers) lymphadenopathy - 3 polyneuropathy - 21 adhesive polyserositis - 5 amyloidösis - 11 bone fractures in 5 spondylopathy in 5. All pts were seropositive 21 had III stage and 11 - IV stage according to x-ray examination. The localisation of AN was as follow: hip - 15 knee - 12 wrist - 3 shoulder - 1 elbow - 1. In 10 pts AN was multiple with second localization: hip (7 pts) and knee (3 pts) joints it appeared during 1 year. All of pts recieved amino-chinolin drugs corticosteroids (Cs) - 10 Cs and cytostatics (C) - 10 only C - 6. Cs and sulfasalasine - 2 Cs and tauredone - 2. All of pts recieved NSAID and Cs intraarticular (1 - 6 time in a year). The initial dose of Cs was no more than 15 - 20 mg of prednisolone pro die. During the course of treatment all of pts recieved sodium fluorid or calcitonin vitamine D3 and retabolil. Besides they recieved pentoxifylline solcoseryl curantyl and local treatment with impulsive magnetic fields and laser-therapy. ... le

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