Attention deficit hyperactivity disorder: Advances in cognitive, neurobiological, and genetic research

Journal/Book: J Child Psychol Psychiat. 1998; 39: 40 West 20TH Street, New York, NY 10011-4211. Cambridge Univ Press. 65-99.

Abstract: Conceptual and technological advances in cognitive neuroscience and molecular genetics have the potential to identify the pathogenesis of psychiatric disorders. This article reviews the application of these technologies to the scientific study of attention deficit hyperactivity disorder. It begins with a summary of shifts in conceptualization and scientific study of this common condition. This is followed by a critical review of findings from recent cognitive, neuroimaging, and genetic studies. The available data do not yet permit an integration across these different levels of enquiry, but implicate problems in response inhibition, dysfunction of frontostriatal networks, and genetic factors in the pathogenesis of this complex behavioral phenotype. The review closes with suggestions for future interdisciplinary research.

Note: Review Tannock R, Hosp Sick Children, Dept Psychiat, Res Unit, 555 Univ Ave, Toronto, ON M5G 1X8, CANADA

Keyword(s): attention deficit disorder; hyperactivity; impulsivity; comorbidity; genetics; neuroimaging; EVENT-RELATED POTENTIALS; CEREBRAL GLUCOSE-METABOLISM; DOPAMINE-RECEPTOR GENE; BASAL GANGLIA VOLUMES; FOLLOW-UP; CORPUS-CALLOSUM; PSYCHIATRIC COMORBIDITY; DEVELOPMENTAL DYSLEXIA; MORPHOMETRIC ANALYSIS; TOURETTES-SYNDROME

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