Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome

Author(s): Kolbe, H., Schneider, U., Emrich, H. M.

Journal/Book: Acta Psychiat Scand. 1998; 98: 35 Norre Sogade, PO Box 2148, Dk-1016 Copenhagen, Denmark. Munksgaard Int Publ Ltd. 502-506.

Abstract: High densities of cannabinoid receptors were found in the basal ganglia and hippocampus, indicating a putative functional role of cannabinoids in movement and behaviour. Anecdotal reports suggested beneficial effects of marijuana in Tourette's syndrome (TS). We therefore interviewed 64 TS patients with regard to use of marijuana and its influence on TS symptomatology. Of 17 patients (27%) who reported prior use of marijuana, 14 subjects (82%) experienced a reduction or complete remission of motor and vocal ties and an amelioration of premonitory urges and obsessive-compulsive symptoms. Our results provide more evidence that marijuana improves ties and behavioural disorders in TS. It can he speculated that cannabinoids might act through specific receptors, and that the cannabinoid system might play a major role in TS pathology.

Note: Article Muller-Vahl KR, Hannover Med Sch, Dept Clin Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, GERMANY

Keyword(s): Tourette's syndrome; tie; marijuana; Cannabis sativa; cannabinoids; RECEPTOR; BRAIN; LOCALIZATION; DISORDERS; BINDING; RATS; D-1

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