Principles of psychoneuroendocrinology

Author(s): Day, H. E. W., Helmreich, D. L., KollackWalker, S., Watson, S. J.

Journal/Book: Psychiat Clin N Amer. 1998; 21: Independence Square West, Curtis Center, Ste 300, Philadelphia, PA 19106-3399. W B Saunders Co. 259.

Abstract: The goal of this article is to describe some of the central nervous system circuits involved in the regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis, with an emphasis on animal models believed to mimic the human experience of emotional stress. First, the basic constitutive elements of the HPA axis that control glucocorticoid secretion are reviewed. A description of the neural systems assumed to regulate the activity of the HPA axis, both anatomically and functionally, follows. It is argued that hypothalamic, septal and bed nucleus of the stria terminalis neurons are involved in the regulation of the HPA axis by situations eliciting emotional responses.

Note: Article Campeau S, Univ Michigan, Mental Hlth Res Inst, 205 Zina Pitcher Pl, Ann Arbor,MI 48109 USA

Keyword(s): CORTICOTROPIN-RELEASING-FACTOR; MESSENGER-RNA EXPRESSION; CORTICOSTEROID-BINDING GLOBULIN; RAT-BRAIN; FACTOR CRF; CHRONIC STRESS; ADRENOCORTICOTROPIN SECRETION; PARAVENTRICULAR NUCLEUS; VASOPRESSIN RECEPTORS; ANTERIOR-PITUITARY

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