Neuroendocrine challenge studies of suicidal behavior

Author(s): Coccaro, E. F.

Journal/Book: Psychiat Clin N Amer. 1997; 20: Independence Square West, Curtis Center, Ste 300, Philadelphia, PA 19106-3399. W B Saunders Co. 563.

Abstract: This article reviews the research data regarding human neuroendocrine systems and suicidal behavior. Special emphasis is placed on pharmacochallenge studies. Such studies uniquely allow for functional assessment of neuroendocrine parameters in living subjects. Serotonergic mechanisms have been the most fruitful areas of research. While discussing the major areas of controversy, theoretical approaches to integration are offered.

Note: Article Coccaro EF, Allegheny Univ Hlth Sci, Med Coll Penn & Hahnemann Univ, Dept Psychiat, Philadelphia,PA 19129 USA

Keyword(s): DEXAMETHASONE SUPPRESSION TEST; GROWTH-HORMONE RESPONSE; SEROTONIN RECEPTOR SENSITIVITY; MAJOR AFFECTIVE-DISORDERS; SERUM CORTISOL-LEVELS; DEPRESSED-PATIENTS; PROLACTIN RESPONSE; D-FENFLURAMINE; M-CHLOROPHENYLPIPERAZINE; INTRAVENOUS TRYPTOPHAN

Zurück | Weiter