Diurnal variation in angiotensin sensitivity in pregnancy

Author(s): Didden, M. A. L., Dejong, P. A.

Journal/Book: Am J Obstet Gynecol. 1996; 174: 11830 Westline Industrial Dr, St Louis, MO 63146-3318. Mosby-Year Book Inc. 259-261.

Abstract: OBJECTIVE: Our purpose was to study the diurnal variation in angiotensin II sensitivity. STUDY DESIGN: Angiotensin sensitivity tests were performed at 9 AM and at 2 PM in 12 normotensive pregnant women, with each woman serving as her own control. RESULTS: In all patients the effective presser dose was higher in the afternoon. CONCLUSION: We suggest the greater sensitivity to angiotensin in the morning is related to an intrinsic circadian variation in vascular reactivity. When the result of an angiotensin sensitivity test is interpreted, the time of day it is performed should be taken into account.

Note: Article FMC Delemarre, Catharina Hosp, Dept Obstet & Gynecol, POB 1350, 5602 Za Eindhoven, Netherlands

Keyword(s): circadian rhythm; angiotensin sensitivity test; pregnancy; ATRIAL-NATRIURETIC-PEPTIDE; BLOOD-PRESSURE; CIRCADIAN VARIATION; RESPONSIVENESS; PREECLAMPSIA; ALDOSTERONE; RHYTHM; RENIN

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