Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice

Author(s): Adler, D. A., Borsani, G., Tsuchiya, K., Franco, B., Hauge, X., Disteche, C., Chapman, V., Ballabio, A.

Journal/Book: Nat Genet. 1995; 10: 466-71.

Abstract: We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.

Note: Comment in: Nat Genet 1995 Aug; 10(4):373

Keyword(s): Chloride Channels [genetics]; Chromosome Mapping

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