P300 assessment of chronic fatigue syndrome

Author(s): Moore, A. P., Wiederhold, M. D.

Journal/Book: J Clin Neurophysiol. 1995; 12: 1185 Ave of the Americas, Journal Subscription Dept, New York, NY 10036. Raven Press. 186-191.

Abstract: The P3(00) event-related brain potential (ERP) was elicited with an auditory tone-discrimination paradigm in 25 patients diagnosed with chronic fatigue syndrome (CFS) and 25 matched normal control subjects. Target stimulus probability was varied systematically (0.20, 0.50, 0.80) in different task conditions. No differences between the CFS and control subjects were found for either P3 amplitude or latency. No group effects were observed for the NI, P2, and N2 components. Despite the attentional and immediate memory deficits reported in CFS, the P3 ERP from auditory stimuli does not reliably discriminate CFS from matched control subjects.

Note: Article J Polich, Scripps Clin & Res Inst, Dept Neuropharmacol TPC 10, 10666 N Torrey Pines Rd, La Jolla, CA 92037 USA

Keyword(s): chronic fatigue syndrome; ERP; P3(00); probability; EVENT-RELATED POTENTIALS; BARR VIRUS-INFECTION; MULTIPLE-SCLEROSIS; RECOGNITION MEMORY; DISEASE; SOMATIZATION; PERFORMANCE; DEFINITION; GENERATORS; DEPRESSION

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