35% CO2 challenge in panic and mood disorders

Author(s): Barbini, B., Cocchi, S., Bertani, A., Gasperini, M.

Journal/Book: J Affective Disord. 1995; 33: PO Box 211, 1000 AE Amsterdam, Netherlands. Elsevier Science Publishers BV. 189-194.

Abstract: 20 patients with Panic Disorder (PD), 19 patients with Mood Disorder (MD) and 20 healthy controls inhaled one vital capacity of 35% CO2-65% O-2 gas mixture and of compressed air in a double-blind, random, cross-over design. Only PD patients showed a strong reaction to 35% CO2 while MD patients and controls did not react significantly. These results support the specificity of the 35% CO2 challenge in PD patients and suggest that PD and MD are separate disorders.

Note: Article G Perna, Univ Milan, Osped San Raffaele, Dept Neuropsychiat Sci, Anxiety Disorders Clin & Res Unit, I-20127 Milan, Italy

Keyword(s): panic; provocation; depression; CO2; CARBON-DIOXIDE INHALATION; SUICIDE ATTEMPTS; ANXIETY; ATTACKS; SENSITIVITY; HYPOTHESIS

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