Sensory modulation of auditory stimuli in children with autism and receptive developmental language disorder: Event-related brain potential evidence

Author(s): Courchesne, E., Harms, L., Allen, M.

Journal/Book: J Autism Dev Disord. 1995; 25: 233 Spring St, New York, NY 10013. Plenum Publ Corp. 521-539.

Abstract: Three groups of age- and PIQ-matched children (Autism, Receptive Developmental Language Disorder, and normal controls) participated in two event-related brain potential (ERP) experiments. Each of these experiments was aimed at evaluating whether either of the two clinical groups of children demonstrated abnormalities in two auditory ERP components N1 and P2, which are known to be dependent on stimulus characteristics (frequency, intensity, and probability), and believed to be generated within primary and secondary cortex. Results of Experiment 1 provide partial support for the idea that both clinical groups failed to fully process changes in stimulus intensity as indexed by the N1 component. Results are discussed in reference to potential abnormalities in serotonergic regulation of auditory cortex.

Note: Article AJ Lincoln, Childrens Hosp, Neuropsychol Res Lab, 8001 Frost St, San Diego, CA 92123 USA

Keyword(s): EVOKED-POTENTIALS; ELECTROPHYSIOLOGIC INDICATION; PROCESSING ABILITIES; INFORMATION; STEM; INTENSITY; CHILDHOOD

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