Effect of lidocaine injection on EOAE in patients with tinnitus

Author(s): Makimoto, K., Araki, M., Kawakami, M., Takahashi, H.

Journal/Book: Acta Oto-Laryngol. 1995; 115: PO Box 2959 Toyen, Journal Division, Customer Service, N-0608 Oslo, Norway. Scandinavian University Press. 488-492.

Abstract: In the present study, evoked otoacoustic emissions (EOAEs) were measured in 30 patients with tinnitus before and after intravenous lidocaine injection (1 mg/kg). For EOAE recordings, 1 kHz tone burst stimuli were used. Intravenous lidocaine injection resulted in suppression of tinnitus in 22 (73%) ears, and changes of EOAE amplitude (increase or decrease) in 18 (60%) ears. Of the 18 ears with EOAE amplitude changes, tinnitus disappeared or decreased in 17 (94%) ears. In 12 ears without changes of EOAE amplitude, tinnitus was suppressed in only 5 (42%). Changes in latency were not detected in any of the ears. These results indicate that there is a relationship between the effect of lidocaine in tinnitus suppression and changes in cochlear micromechanics caused by lidocaine.

Note: Article S Haginomori, Osaka Med Coll, Dept Otolaryngol, 2-7 Daigakucho, Takatsuki, Osaka 569, Japan

Keyword(s): cochlear micromechanics; efferent auditory pathway; OUTER HAIR-CELLS; EVOKED OTOACOUSTIC EMISSIONS; ACOUSTIC EMISSIONS; LIGNOCAINE; MOTILITY; HEARING

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