Neomycin-induced perception deafness following bladder irrigation in patients with end-stage renal disease

Author(s): Weingartner, K., Melekos, M. D., Varga, S., Feiber, H., Riedmiller, H.

Journal/Book: Brit J Urol. 1995; 76: Osney Mead, Oxford, Oxon, England OX2 0EL. Blackwell Science Ltd. 479-481.

Abstract: Objective To report a serious side-effect of intravesical instillations of neomycin in patients with end-stage renal disease. Patients and methods Three patients (two men and a woman, aged 51,71 and 54 respectively) with endstage renal disease who had undergone bladder irrigation with neomycin sulphate solution suffered complete irreversible deafness, which was assessed by audiogram. Results All three patients developed complete perception deafness after 3, 4 and 10 months, with characteristic changes in the audiogram, The severe progressive hearing loss was maximal in the high-frequency range. A high-pitched tinnitus was the first sign of impending hearing difficulty and two patients developed a spontaneous nystagmus. Conclusion In view of the doubtful efficacy and, most importantly, the risk of severe disabling side-effects such as ototoxicity, we recommend the avoidance of intravesical instillation with neomycin whenever possible.

Note: Article EW Gerharz, Univ Marburg Klinikum, Zentrum Operat Med 2, Urol Klin, Baldingerstr, POB 2360, D-35033 Marburg, Germany

Keyword(s): ototoxicity; neomycin; bladder irrigation; chronic renal failure; TOXICITY

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