Immunmodulatorische Wirkung lebender nicht-pathogener Enterococcus faecalis-Bakterien des Menschen

Author(s): Grundmann, E.

Journal/Book: Arzneimittel-Forschung / Drug Research. 1994; 44 (I), 5: 691-695.

Abstract: Immunomodulating Effect of Living Nonpathogenic Enterococcus faecalis Originated. From Humans Symbioflor 1® is a pharmaceutical preparation, consisting of a suspension of living nonpathogenic Enterococcus faecalis (E faecalis). The effect an the liberation of cytokines of E. faecalis was investigated in in-vitro experiments with human peripheral mononuclear bloodcells revealing the föllowing results:1. E. faecalis stimulates the liberation of' interleukin 1 (IL-Iß) and interleukin-6 (IL-6) in a dose-dependent manner- the E faecalis induced liberation of IL1 fl and IL-6 is inhibited by dexamethasone (Dm) but not by ciclosporin A (CsA).2. E faecalis stimulates the liberation of gamma-interferon (IFN-y) in a dose-dependant manner, which is inhibited by both Dm and CsA.3. Plrytohemagglutinin (PHA)-induced liberation of y-IFN and interleukin-2 (IL-2) is inhibited by E. faecalis in a dose-dependent manner.The relevancy, to clinical trials of the in vitro results is discussed.

Keyword(s): Cytokine, liberation

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