Randomized Placebo-Controlled Double-Blind Study of the Clinical Efficacy of the Homeopathic Euphorbium compositum S Nasal Spray in Cases of Chronic Sinusitis

Author(s): Clasen, B.

Abstract: Objective: Study of the clinical efficacy of Euphorbium compositum-Nasentropfen S (Euphorbium compositum S nasal spray) in cases of chronic sinusitis.Design: Randomized, placebo-controlled double-blind study over a 5-month period (prospectively).Patients: Only those patients were included in this study who suffered from established, chronically recurrent - although not acute - rhinosinusitis, for whom conservative therapy was indicated during symptom-free intervals. Excluded from the study were patients who smoked, who suffered from nasoendoscopically confirmed polyposis or infectious rhinitis, who were known to possess unhealed apical granulomata, whose cases of sinusitis were established to be odontogenous, or who had undergone surgical treatment within the previous 6 months. The investigation encompassed a total of 173 patients, 155 of whom were included in the final evaluation (89.6%).Interventions: Two discharges of verum or placebo into each nostril 4 times dailyover a period of 5 months.Main Outcome Measures: For the purpose of statistical comparison of the therapeutic groups, a cumulative score was calculated from the data compiled in the 3 sectors subjective symptoms (day/night)', 'anterior rhinoscopy', and 'ultrasound examination of the paranasal sinus'.Results: Statistical comparison of the therapeutic collectives demonstrates a significant superiority of Euphorbium compositum S nasal spray (5% significance level, p=0.016). Improvement was most evident within the subjective criteria of respiratory obstruction, sensation of pressure, and headache. Euphorbium compositum S nasal spray was well tolerated.Conclusions: This study substantiates the reliable efficacy and good tolerance of Euphorbium compositum S nasal spray in the therapy of chronic sinusitis. In addition, it demonstrates maintenance of a high standard of methods and acquirement of meaningful test results to indeed be feasible in homeopathy.

Keyword(s): Euphorbium compositum-Nasentropfen S

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