Chem Pharm Bull (Tokyo). 1991 Mar; 39(3): 690-2.

Pharmacological properties of galenical preparation. XIV. Body temperature retaining effect of the Chinese traditional medicine, "goshuyu-to" and component crude drugs.

Kano Y, Zong QN, Komatsu K.

Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan.

We orally administered Goshuyu-to or Evodia fruit extract and Ginger extract to untreated rats, and found a slight but not significant rise in their body temperature. In rats treated with chlorpromazine, the administration of Goshuyu-to prevented decrease in the body temperature. After administration of each extract of component crude drugs (Evodia fruit, Ginger, Ginseng: Jujube: such an effect was recognized only by Evodia fruit, and other component crude drugs exhibited no body temperature retaining effect in this experiment system. We further studied the effect of Evodia fruit alkaloid hydroxyevodiamine, evodiamine, rutaecarpine and evocarpine used individually and confirmed that the body temperature retaining effect occurred mainly with evodiamine.