Wirksamkeit von LI 1370 bei älteren Patienten mit Hirnleistungsschwäche - Multizentrische SDoppelblindstudie des Fachverbandes Deutscher Allgemeinärzte

Author(s): Heinrich, S., Ruf-Kohler, P.

Journal/Book: Münchener Medizinische Wochenschrift. 1991; 133: 9-14.

Abstract: Efficacy of Ll 1370 in Elderly Patients with Cerebral Insufficiency: Multicentric Double-blind Trial by the German Association of Ge-neral Practioners: In 33 general practitioners' practices a placebo-controlled double-blind study concerning the efficacy of a Ginkgo bi-loba special extract in elderly patients with cerebral insufficiency was carried out with 303 outpatients. The dosage was 3 x 1 coated tablet of 50 mg Ginkgo biloba special extract daily for 12 weeks. Controls took place after the 6th and 12th therapy week. Signs of cerebral insufflciency as well as the figure connection test and at the end of the therapy the doctor's and patient's judgement on the efficacy of the preparation were taken into account. 209 protocols were available for the statistical evaluation. Statistically sig-nificant improvements were demonstrated after 6 weeks of therapy on 3 out of 11 typical symptoms and after 12 weeks of therapy on 8 out of 11. In the active group the time peri-od for the figure connection test was improv-ed by 25%, in the placebo group only by 14% (p < 0,01 in comparison between the groups). Both the doctor's and the patient's judgement concerning the efficacy show highly significant differences between the two groups. The incidence of side effects was as half as high in the verum group com-pared to the placebo group.

Keyword(s): Ginkgo biloba

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