In vitro Simulaton of Human granulocytes and Lymphocytes by Pico- an Fentogram Quantities of Cytostatic Agents

Author(s): Kicher, B., Jurcic, K.

Journal/Book: Arzneimittel-Forschung/Ding-research. 1988; 38: 273-275.

Abstract: The influence of a broad concentration range of naturally occurring naphthoquinones and other cytotoxic or cytostatic agents (azathioprine, colchicine, cyclophosphamide, fluorouracil, methotrexate and vincristine) on human granulocytes and Iymphocytes was investigated in a systematic in vitro study. At high concentrations (100 ?g10 ng/ ml) nearly all substances showed the known cytotoxic or immunosuppressive effects, whereas most of the same compounds displayed immunostimulating activities at very low concentrations (10 ng10 fg/ml).After a cold shock or heat treatment Iymphocytes became more sensitive against these compounds in the active concentration range than untreated cells.These results possibly give an explanation for the antitumour activity of some plant extracts, for which a direct cytotoxicity due to the applied low dose can be excluded.

Keyword(s): Cytostatic

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