Biochemical and clinical effects of treating the premenstrual syndrome with prostaglandin synthesis precursors

Author(s): Mäkränäinen, L., Viinikka, Ylikorkala, O.

Journal/Book: Journal of Reproductive Medicine. 1985; 30: 149-153.

Abstract: The clinical and biochemical effects of a prostaglandin synthesis precursor (Efamol) containing linoleic acid and its metabolite, y-linolenic acid, were studied in 30 women with severe, incapacitating premenstrual syndrome. Efamol treatment alleviated the premenstrual symptoms in general and depression especially better than did a placebo.The capacity of platelets to release thromboxane BZ during spontaneous clotting was decreased in patients undergoing Efamol treatment (141 ±59 ng/ml, mean ± SD) as compared to those undergoing Placebo treatment (186±44 ng/ml; p<0.01) and control subjects (176±40 ng/ml, n=25, p<0.05). No changes were found in plasma 6-keto-prostaglandin F1? or in FSH, LH, prolactin, progesterone, estradiol and testosterone.The data suggest that prostaglandins-might play a role in the pathophysiology of the premenstrual syndrome.

Keyword(s): klinische Studie

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